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Neutralization of nanoparticles in lung cells

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How does the body react to inhaled nanoparticles? In a collaboration involving researchers from the MEANS team at the MPQ laboratory, the evolution of molybdenum disulfide nanosheets in mouse lungs has been monitored for up to one month after inhalation. Published in the journal Advanced Materials, this work shows that pulmonary macrophages can transform these nanoparticles and roll them up in order to reduce their contact surface, and thus their toxicity, and would also be able to modulate the induced inflammatory reaction.

The fate of nanoparticles in the biological environment is the subject of important monitoring. The evaluation of their toxicity in the human body thus requires an understanding of the inflammatory reactions that they can cause. Among the nanoparticles of interest, molybdenum disulfide (MoS2) is a graphene analogue widely used by industry, notably as a mechanical lubricant, which can be involuntarily inhaled. Researchers from the laboratories Matière et systèmes complexes (MSC, CNRS/Université Paris Cité), Matériaux et phénomènes quantiques (MPQ, CNRS/Université Paris Cité), Immunologie, immunopathologie et chimie thérapeutique (I2CT, CNRS) and Institut Galien Paris-Saclay (IGPS, CNRS/Université Paris-Saclay) have studied the long-term persistence of MoS2 nanosheets in the lungs of mice exposed to them. Thus, they have exploited liquid-phase electron microscopy to identify three mechanisms of transformations of these nanoparticles while monitoring different biomarkers of inflammation in the lungs.

These results have been highlighted in a CNRS INSIS news article

Successive TEM images in a medium mimicking the intracellular environment of the transformation dynamics of nanosheets.

MPQ Contact:
Damien Alloyeau (damien

Resolution of MoS2 nanosheets-induced pulmonary inflammation driven by nanoscale intracellular transformation and extracellular-vesicle shuttles, Nathaly Ortiz Peña, Kondareddy Cherukula, Benjamin Even, Ding-Kun Ji, Sarah Razafindrakoto, Shiyuan Peng, Amanda K. A. Silva, Cécilia Ménard Moyon, Hervé Hillaireau, Alberto Bianco, Elias Fattal, Damien Alloyeau, Florence Gazeau, Advanced Materials 2209615 (2023)